Eat at any of the four brasseries—themed according to different regions of France—run by Paul Bocuse, the veteran French chef who gave the world its first taste of nouvelle cuisine back in the 1970s.

Ride the funicular railway up to the crest of Fourvière Hill for spectacular views of the city from beside the monumental basilica of Notre Dame.

Drink on the terrace of the Villa Florentine, a former convent that’s now a swank hotel, perched on a hillside just above the core of medieval Lyon (www.villaflorentine.com).

Admire the treasures of the Textiles Museum, an elegant 18th-century town house—once the home of the city’s governor—that celebrates Lyon as the historic center of Europe’s silk industry (www.musee-des-tissus.com).

Shop for antiques or silk in the grid of elegant streets south of Place Bellecour in the Presque’île district, the favored haunt for collectors.